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Is Benadryl Safe for Dogs?

Written by The Halo Team

October 2, 2024

Benadryl is a common over-the-counter medication for allergy symptoms, including sneezing, runny nose and itchy, watery eyes. Many pet owners may consider giving it to their four-legged family members to treat the same issues, calm anxious dogs or treat itchy skin caused by insect bites or environmental allergens.

Although Benadryl has been given to dogs safely, it should only be used under a vet’s guidance. However, if you want to learn more about how and when to give a dog Benadryl, this comprehensive guide covers safety, dosage, benefits and potential side effects of using this human medication for dogs.

What Is Benadryl?

Benadryl is the brand name for an antihistamine containing the active ingredient diphenhydramine. It works by blocking histamine receptors in the body, relieving allergies and related symptoms in humans. Although it’s not FDA-approved as a veterinary medicine, it’s used by veterinarians nationwide to treat dogs and cats. Common veterinary uses of Benadryl for dogs include relieving mild to moderate seasonal, environmental and food allergies. It may also be used to treat anxiety and motion sickness.

Can Dogs Take Benadryl?

Benadryl is generally well-tolerated in canines when administered correctly and in the appropriate dosage. It’s usually considered safe for short-term use if your dog is healthy, with few side effects and a low risk of overdose. However, it’s crucial to consult a veterinarian before giving your dog this or any other medication meant for humans.

Before deciding to use Benadryl, your vet must evaluate the appropriateness of using the medication based on your dog’s health, medical history and breed. Dogs with certain medical conditions aren’t good candidates for taking Benadryl.

Benadryl Dosage for Dogs

According to the Merck Veterinary Manual, the recommended Benadryl dosage for dogs is 2 to 4 milligrams per kilogram of body weight (about 1 milligram per pound), given orally every 8 to 12 hours as needed. How much Benadryl to give your dog varies based on many factors, including its age and existing health conditions.

Benadryl comes in different forms, including tablet, liquid and chewable. Never give your pet the time-release capsules, as these are absorbed differently in dogs than humans, which could impact dosage. Plus, capsules can break open if chewed, causing your dog to get too much medicine at once and risking a Benadryl overdose.

When choosing liquid Benadryl for dogs, avoid any containing sodium or alcohol. Also, avoid any form of Benadryl combined with other medications, such as decongestants, which can be harmful to your pet. Your vet can prescribe a flavored chewable if your dog doesn’t take the tablet or liquid form.

Recommended ways for administering this medicine to your dog include mixing liquid Benadryl with food or squirting it directly into its mouth with an oral syringe. Tablets may be given whole or crushed in food, treats, pill pockets or something similar.

Never give your dog Benadryl without consulting your veterinarian to ensure its safety. Your vet can tell you the correct dosage for your dog to prevent adverse effects, including possible death. You must also confirm your dog has no health conditions that make it unadvisable to take human Benadryl.

Potential Side Effects of Benadryl in Dogs

Like any medication, Benadryl has potential side effects. Common mild side effects include:

  • Drowsiness
  • Dry mouth
  • Decreased urination
  • Mild sedation

Less common but more severe side effects can include:

  • Rapid breathing
  • Increased heart rate
  • Diarrhea
  • Vomiting

Your dog can have an anaphylactic reaction to Benadryl, which is a severe allergic reaction. Seek immediate veterinary attention should this occur. If you miss a dose, don’t double up on the next one, as this could potentially cause an overdose. Signs of Benadryl overdose include hyperactivity, seizures and extreme lethargy. Potentially fatal overdoses can lead to respiratory failure, so seek emergency veterinary care.

Vet examining a dog.

When Not to Use Benadryl for Dogs

Under certain circumstances, dogs shouldn’t be given Benadryl to treat allergies or other issues. Dogs with preexisting heart conditions, glaucoma, liver disease, seizure disorders, difficulty urinating, and certain lung conditions usually aren’t good candidates for taking Benadryl. Giving this medicine to pregnant or nursing dogs also isn’t recommended. Certain breeds, such as bulldogs, pugs and other brachycephalic dogs, are more sensitive to antihistamines. If your dog takes other medication, seek veterinary guidance before giving it Benadryl.

Alternatives to Benadryl for Dogs

If Benadryl isn’t the best option for your dog, several alternatives are available to manage allergies. Natural alternatives like CBD oil may relieve pain, anxiety and itchiness, offering calming benefits. Chamomile and other herbal remedies may work as anti-inflammatories, but some dogs are sensitive to them, so consult your veterinarian before use.

Benadryl is a first-generation antihistamine, while over-the-counter alternatives, such as Zyrtec and Claritin, are second-generation antihistamines. Second-generation options may be the better choice as they generally have fewer side effects, such as drowsiness. They also interact with fewer medications and work longer, so your dog needs fewer doses.

Prescription options such as Apoquel or Cytopoint provide targeted relief for more acute allergic reactions. They typically offer longer-lasting effects for chronic skin allergies and itching. Your vet can advise you on the best fit for your dog’s symptoms.

Bye-Bye Allergies, Halo Happy Pup!

Benadryl can be a safe, effective option for treating allergies and anxiety in dogs when used under a vet’s guidance and at the correct dosage. Understanding your dog’s health, weight and overall needs is crucial to safe administration.

Natural alternatives such as CBD oil or chamomile and other over-the-counter or prescription medications are additional options to consider. No matter your decision, always consult with your vet to determine the best route to keep your dog comfortable and healthy.

As part of your proactive approach to your dog’s overall care and safety, check out the new Halo Collar 4. It can be a game changer for your pet’s well-being and your peace of mind. Share your dog safety stories in the comments below, or learn more about safety, wellness and training in the Halo blog.

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